Exploring Potential for a Personalized Medicine Approach to Smoking Cessation With an American Indian Tribe.

ABSTRACT:

Introduction

A potential precision medicine approach to smoking cessation is tailoring pharmacotherapy to a biomarker known as the nicotine metabolite ratio (NMR). Little is known about the potential impact and acceptability of this approach for American Indian (AI) persons.

Aims and methods

Tribal-academic collaboration was formed and during 2019-2020 AI adults who smoke(N = 54) were recruited to (1) examine correlations between NMR, dependence, and smoking exposure; (2) assess the extent to which pharmacotherapy preference aligned with NMR-informed recommendations; (3) explore acceptability of NMR-informed pharmacotherapy selection. Participants provided samples for assessment of salivary NMR and urinary total nicotine equivalents (TNE) and completed a questionnaire that a

SUBMITTER: Carroll DM 

PROVIDER: S-EPMC9717394 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature