Dysregulated long non-coding RNA in Sjogren's disease impacts both interferon and adaptive immune responses.

ABSTRACT:

Objective

Sjögren's disease (SjD) is an autoimmune disease characterised by inflammatory destruction of exocrine glands. Patients with autoantibodies to Ro/SSA (SjD^Ro+) exhibit more severe disease. Long non-coding RNAs (lncRNAs) are a functionally diverse class of non-protein-coding RNAs whose role in autoimmune disease pathology has not been well characterised.

Methods

Whole blood RNA-sequencing (RNA-seq) was performed on SjD cases (n=23 Ro/SSA negative (SjD^Ro-); n=27 Ro/SSA positive (SjD^Ro+) and healthy controls (HCs; n=27). Bioinformatics and pathway analyses of differentially expressed (DE) transcripts (log₂ fold change ≥2 or ≤0.5; p_adj<0.05) were used to predict lncRNA function. LINC01871 was characterised by

SUBMITTER: Joachims ML 

PROVIDER: S-EPMC9717416 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature