System for delivering microwave ablation to subcutaneous tumors in small-animals under high-field MRI thermometry guidance.

ABSTRACT:

Purpose

Bio-effects following thermal treatments are a function of the achieved temperature profile in tissue, which can be estimated across tumor volumes with real-time MRI thermometry (MRIT). Here, we report on expansion of a previously developed small-animal microwave hyperthermia system integrated with MRIT for delivering thermal ablation to subcutaneously implanted tumors in mice.

Methods

Computational models were employed to assess suitability of the 2.45 GHz microwave applicators for delivering ablation to subcutaneous tumor targets in mice. Phantoms and ex-vivo tissues were heated to temperatures in the range 47-67 °C with custom-made microwave applicators for validating MRIT with the proton resonance frequency shift method against fiberoptic thermometry. HAC1

SUBMITTER: Sebek J 

PROVIDER: S-EPMC9717487 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature