Identification of bacteria-derived HLA-bound peptides in melanoma.

ABSTRACT: A variety of species of bacteria are known to colonize human tumours^1-11, proliferate within them and modulate immune function, which ultimately affects the survival of patients with cancer and their responses to treatment^12-14. However, it is not known whether antigens derived from intracellular bacteria are presented by the human leukocyte antigen class I and II (HLA-I and HLA-II, respectively) molecules of tumour cells, or whether such antigens elicit a tumour-infiltrating T cell immune response. Here we used 16S rRNA gene sequencing and HLA peptidomics to identify a peptide repertoire derived from intracellular bacteria that was presented on HLA-I and HLA-II molecules in melanoma tumours. Our analysis of 17 melanoma metastases (derived from 9 patients) revealed 24

SUBMITTER: Kalaora S 

PROVIDER: S-EPMC9717498 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature