Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is a fatal malignant primary brain tumor in adults. The therapeutic efficacy of chemotherapeutic drugs is limited due to the blood-brain barrier (BBB), poor drug targeting, and short biological half-lives. Multifunctional biomimetic nanodrugs have great potential to overcome these limitations of chemotherapeutic drugs.

Methods

We synthesized and characterized a biomimetic nanodrug CMS/PEG-DOX-M. The CMS/PEG-DOX-M effectively and rapidly released DOX in U87 MG cells. Cell proliferation and apoptosis assays were examined by the MTT and TUNEL assays. The penetration of nanodrugs through the BBB and anti-tumor efficacy were investigated in the orthotopic glioblastoma xenograft models.

Results

We showed that CMS/PEG-DOX-M inhibited

SUBMITTER: Yao Z 

PROVIDER: S-EPMC9717509 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature