Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Gottingen Minipig model.

ABSTRACT:

Background

Gut microbiota dysbiosis is associated with the development of non-alcoholic steatohepatitis (NASH) through modulation of gut barrier, inflammation, lipid metabolism, bile acid signaling and short-chain fatty acid production. The aim of this study was to describe the impact of a choline-deficient amino acid defined high fat diet (CDAHFD) on the gut microbiota in a male Göttingen Minipig model and on selected pathways implicated in the development of NASH.

Results

Eight weeks of CDAHFD resulted in a significantly altered colon microbiota mainly driven by the bacterial families Lachnospiraceae and Enterobacteriaceae, being decreased and increased in relative abundance, respectively. Metabolomics analysis revealed that CDAHFD decreased colon content of short-chain fa

SUBMITTER: Lutzhoft DO 

PROVIDER: S-EPMC9717514 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature