Autoinflammatory disease: clinical perspectives and therapeutic strategies.

ABSTRACT: The molecular platforms of the innate immune system are essential to recognize pathologic external factors that are crucial to differentiate these danger signals from host motifs. A set of sensors recognizing pathologic factors is present and defined as a membrane-bound family of Toll-like receptors as well as the cytosolic ones including the family of nucleotide-binding domain leucine-rich repeat proteins. In this regard, the inflammasomes have been identified as an innate immune sensor toward pathologic external factors as well as endogenous damage-associated molecular pattern signals transducing from the above-mentioned receptors to gene expressions. Recent research has shown novel findings in inflammasome biology and genetics which lead to the alteration of diagnosis and management in

SUBMITTER: Kawakami A 

PROVIDER: S-EPMC9717532 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature