Osteoarthritis and cardiovascular disease: A Mendelian randomization study.

ABSTRACT:

Objective

This Mendelian randomization (MR) study aimed to investigate the causal relationship between osteoarthritis (OA) and cardiovascular disease (CVD).

Methods

From a genome-wide association study of European ancestry, we selected single nucleotide polymorphisms for two types of OA, knee osteoarthritis (KOA) and hip osteoarthritis (HOA), as instrumental variables. We evaluated three types of CVD: coronary heart disease (CHD), heart failure (HF), and stroke. We used the traditional inverse variance weighting (IVW) method and other methods to estimate causality. Heterogeneity and sensitivity tests were also applied. Finally, we conducted a MR analysis in the opposite direction to investigate reverse causality.

Results

IVW analysis showed that HOA significantly affe

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9717609 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature