Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.

ABSTRACT:

Background

The incidence of anal cancer is substantially higher among persons living with the human immunodeficiency virus (HIV) than in the general population. Similar to cervical cancer, anal cancer is preceded by high-grade squamous intraepithelial lesions (HSILs). Treatment for cervical HSIL reduces progression to cervical cancer; however, data from prospective studies of treatment for anal HSIL to prevent anal cancer are lacking.

Methods

We conducted a phase 3 trial at 25 U.S. sites. Persons living with HIV who were 35 years of age or older and who had biopsy-proven anal HSIL were randomly assigned, in a 1:1 ratio, to receive either HSIL treatment or active monitoring without treatment. Treatment included office-based ablative procedures, ablation or excision under anes

SUBMITTER: Palefsky JM 

PROVIDER: S-EPMC9717677 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature