Ventilatory ratio, dead space, and venous admixture in acute respiratory distress syndrome.

ABSTRACT:

Background

Ventilatory ratio (VR) has been proposed as an alternative approach to estimate physiological dead space. However, the absolute value of VR, at constant dead space, might be affected by venous admixture and CO₂ volume expired per minute (VCO₂).

Methods

This was a retrospective, observational study of mechanically ventilated patients with acute respiratory distress syndrome (ARDS) in the UK and Italy. Venous admixture was either directly measured or estimated using the surrogate measure Pa_O2/FiO₂ ratio. VCO₂ was estimated through the resting energy expenditure derived from the Harris-Benedict formula.

Results

A total of 641 mechanically ventilated patients with mild (n=65), moderate (n=363), o

SUBMITTER: Maj R 

PROVIDER: S-EPMC9718027 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature