Five-Year Symptom Trajectories in Nondialysis-Dependent CKD Patients.

ABSTRACT:

Background and objectives

Late stages of CKD are characterized by significant symptom burden. This study aimed to identify subgroups within the 5-year trajectories of symptom evolution in patients with CKD and to describe associated patient characteristics and outcomes.

Design, setting, participants, & measurements

Among 2787 participants (66% men) with eGFR <60 ml/min per 1.73 m² enrolled in the CKD-Renal Epidemiology and Information Network (CKD-REIN) cohort study from July 2013 to May 2016, we assessed symptoms annually using the Kidney Disease Quality of Life-36 (KDQOL-36) questionnaire until December 2020. A total of 9121 measures were reported over follow-up; all participants had symptoms scored for at least one time point. We used a joint latent class-mixed

SUBMITTER: Faye M 

PROVIDER: S-EPMC9718050 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature