Patterns of progression differ between Kellgren-Lawrence 2 and 3 knees fulfilling different definitions of a cartilage-meniscus phenotype in the Foundation for National Institutes of Health Osteoarthritis Biomarkers study (FNIH).

ABSTRACT:

Objective

Aim was to describe three definitions for an MRI-defined cartilage-meniscus phenotype and to report phenotypic progression in Kellgren-Lawrence (KL) 2 and 3 knees over 48 months.

Methods

The study sample was a nested case-control study with knees showing either 1) radiographic and pain progression ("composite" case), 2) radiographic progression only, 3) pain progression only, and 4) no progression. MRI was performed on 3T systems. MRIs were read according to the MOAKS system. Knees were classified as having the cartilage-meniscus phenotype according to three modified ROAMES (Rapid OsteoArthritis MRI Eligibility Score) definitions (D): 1) ​≤ ​2.2 (10-75% of the region of cartilage surface area with 10-75% affected by full thickness loss), i.e. 'D1' 2) ≤ 2.1 (10-75%

SUBMITTER: Roemer FW 

PROVIDER: S-EPMC9718096 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature