Cartilage collagen neoepitope C2C in urine as an integrative diagnostic marker for early knee osteoarthritis.

ABSTRACT:

Objective

To investigate the suitability of urinary collagen type-II C-terminal cleavage neoepitope (uC2C) as a marker for early knee osteoarthritis (kOA).

Design

We examined 302 Estonian subjects (mean age, 49 years): 186 subjects with and 20 control subjects without knee symptoms, and 96 patients treated by arthroscopy. For the latter, cartilage lesions were characterized using Société Francaise d'Arthroscopie (SFA) scores. Standardized radiographs of bilateral tibiofemoral (TF) and patellofemoral (PF) joints were assessed for osteoarthritis (OA) features. Osteophytes (Ophs) and joint space narrowing (JSN) were graded separately. uC2C was measured by the uC2C-HUSA assay. Logistic and linear regression models were used for data analysis.

Results

Of the kOA cases, 50%

SUBMITTER: Kuhi L 

PROVIDER: S-EPMC9718127 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature