A simple inclusion criteria combination increases the rate of cartilage loss in patients with knee osteoarthritis.

ABSTRACT:

Objectives

Selection of patients with KL radiographic grade 2 and 3 is widely used in clinical trials, but this approach could have some limitations. The purpose of this study performed on OsteoArthritis Initiative (OAI) data is to assess whether adding OARSI-JSN to KL grading could select a population with increased rate of cartilage loss. Indeed, KL is not compartment-specific and not uniformly graded amongst expert readers. OARSI-JSN is another established, compartment-specific grading scale that specifically captures the joint space narrowing from radiographs.

Design

1019 knee radiographs data from the progression cohort of the OAI public database were used. Cartilage loss measured with magnetic resonance imaging was evaluated using change over 1 year from baseline in ca

SUBMITTER: Imbert O 

PROVIDER: S-EPMC9718131 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature