The association of plasma IL-1Ra and related cytokines with radiographic severity of early knee osteoarthritis.

ABSTRACT:

Objective

We aimed to evaluate the association between inflammatory biomarkers in peripheral blood and severity of knee osteoarthritis (OA).

Methods

We performed a cross-sectional study in participants with frequent knee pain, evaluated radiographic and clinical severity. We measured inflammatory biomarkers: plasma (p) IL-1Ra, IL-1β, IL-18, serum (s) CD14, hsCRP and bone and cartilage biomarkers: urine (u) CTX-II, (s) HA, COMP, CTX-I, PIIANP. We assessed radiographic severity by Kellgren-Lawrence (KL) grading and Osteoarthritis Research Society International (OARSI) standardized scoring atlas; and clinical severity by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).

Results

139 participants (82% women, mean ± SD age: 55.5 ± 7.8 years) were i

SUBMITTER: Ma CA 

PROVIDER: S-EPMC9718200 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature