Evaluating plasma extracellular vesicle microRNAs as possible biomarkers for osteoarthritis.

ABSTRACT:

Objective

MicroRNAs (miRNAs) are being launched as biomarkers for various diseases, but a robust biomarker for articular cartilage pathology has yet to be discovered. Here we evaluate plasma extracellular vesicle (EV) miRNAs as possible biomarkers for osteoarthritis (OA).

Method

We compared miRNA levels found in plasma EVs from patients with OA with controls without OA using next generation sequencing (NGS) technique. The patient and control pairs were matched for age, gender and body mass index.

Results

23 pairs of patients and controls were included. Patients with OA differed significantly from controls in both clinical and radiological assessment of OA. We identified 177 canonical miRNAs in plasma EVs, but found no difference in miRNA levels between the two groups.

SUBMITTER: Aae TF 

PROVIDER: S-EPMC9718208 | biostudies-literature | 2020 Jan-Feb

REPOSITORIES: biostudies-literature