Interventions for osteoarthritis pain: A systematic review with network meta-analysis of existing Cochrane reviews☆

ABSTRACT:

Objective

To conduct a network meta-analysis comparing all treatments for osteoarthritis (OA) pain in the Cochrane Library.

Design

The Cochrane Library and Epistemonikos were searched for randomized controlled trials (RCTs) about treatments for hip and knee OA. We constructed 17 broad categories, comprising drug treatments, exercise, surgery, herbs, orthotics, passive treatments, regenerative medicine, diet/weight loss, combined treatments, and controls. In addition to a full network analysis, we compared the direct/indirect effects, and studies with shorter-/longer follow-up. CINeMA software was used for assessing confidence in network meta-analysis estimates.

Results

We included 35 systematic reviews including 445 RCTs. There were 153 treatments for OA. In tota

SUBMITTER: Smedslund G 

PROVIDER: S-EPMC9718209 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature