In vivo mechanotransduction: Effect of acute exercise on the metabolomic profiles of mouse synovial fluid.

ABSTRACT:

Objective

Exercise is known to induce beneficial effects in synovial joints. However, the mechanisms underlying these are unclear. Synovial joints experience repeated mechanical loading during exercise. These mechanical stimuli are transduced into biological responses through cellular mechanotransduction. Mechanotransduction in synovial joints is typically studied in tissues. However, synovial fluid directly contacts all components of the joint, and thus may produce a whole-joint picture of the mechanotransduction response to loading. The objective of this study was to determine if metabolic phenotypes are present in the synovial fluid after acute exercise as a first step to understanding the beneficial effects of exercise on the joint.

Material and methods

Mice underwent a

SUBMITTER: Hahn AK 

PROVIDER: S-EPMC9718234 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature