Assessing in vivo articular cartilage mechanosensitivity as outcome of high tibial osteotomy in patients with medial compartment osteoarthritis: Experimental protocol.

ABSTRACT:

Objective

To propose an experimental protocol for using high tibial osteotomy (HTO) as a model for studying in vivo biological effects of large permanent changes in ambulatory load.

Design

This study is a prospective multimodal (clinical, biomechanical, biological) data collection without randomization. The study will examine a cohort of 40 patients with medial compartment knee OA undergoing opening wedge HTO.

Experimental protocol

Before planned HTO, patients will be clinically assessed (including mechanical axis measurement from radiographs) and complete questionnaires on physical function. Patients will complete a walking stress test with blood sampling (30 min walking, 5.5 h sitting), and undergo gait analysis. Six weeks after HTO (at the time of full weight beari

SUBMITTER: Mundermann A 

PROVIDER: S-EPMC9718245 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature