The association between vitamin K and medial tibial-femoral knee osteoarthritis progression: Data from the osteoarthritis initiative

ABSTRACT:

Objective

We sought to examine the prospective association of vitamin K with radiographic progression of knee osteoarthritis.

Methods

In OAI, 1977 participants with radiographic knee OA and having dietary data at baseline were followed up to 12, 24, 36 and 48 months. Vitamin K was assessed with a Block Brief Food Frequency Questionnaire completed at baseline. To evaluate knee OA progression, we used quantitative medial tibiofemoral joint space width (JSW) based on plain radiographs. Progression was defined by measured Joints Space Width (JSW). The generalized linear mixed model was used to test the association of vitamin K and change in JSW over time, while adjusting for baseline KL grade and other potential confounding factors.

Results

We found a relationship be

SUBMITTER: Horace R 

PROVIDER: S-EPMC9718276 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature