Design of a novel multiple epitope-based vaccine: an immunoinformatics approach to combat monkeypox.

ABSTRACT: Monkeypox virus is an infectious agent that causes fever, Pneumonitis encephalitis, rash, lymphadenopathy and bacterial infection. The current outbreak of monkeypox has reawakened the global health concern. In the current situation of increasing viral infection, no vaccine or drug is available for monkeypox. Thus, there is an urgent need for viable vaccine development to prevent viral transmission by boosting human immunity. Herein, using immunoinformatics approaches, a multi-epitope vaccine was constructed for the Monkeypox virus. In this connection, B-Cell and T-cell epitopes were identified and joined with the help of adjutants and linkers. The vaccine construct was selected based on promising vaccine candidates and immunogenic potential. Further epitopes were selected based on antigeni

SUBMITTER: Hayat C 

PROVIDER: S-EPMC9718376 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature