Structural analysis of SARS-CoV-2 Spike protein variants through graph embedding.

ABSTRACT: Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected almost all countries. The unprecedented spreading of this virus has led to the insurgence of many variants that impact protein sequence and structure that need continuous monitoring and analysis of the sequences to understand the genetic evolution and to prevent possible dangerous outcomes. Some variants causing the modification of the structure of the proteins, such as the Spike protein S, need to be monitored. Protein contact networks (PCNs) have been recently proposed as a modelling framework for protein structures. In such a framework, the protein structure is represented as an unweighted graph whose nodes are the central atoms of the backbones (C- α ), and edges connect two atoms falling in

SUBMITTER: Guzzi PH 

PROVIDER: S-EPMC9718452 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature