Adverse childhood experiences and premature mortality through mid-adulthood: A five-decade prospective study.

ABSTRACT:

Background

Adverse childhood experiences (ACEs) can have lasting effects on adult health and survival. In this study, we aimed to examine how the cumulative number and clustering patterns of ACEs were related to premature mortality.

Methods

Participants (N=46 129; 45% White, 48% Black; 49·5% females) were offspring (born in 1959-1966) of participants enrolled in the Collaborative Perinatal Project (CPP). We conducted latent class analysis to examine the clustering patterns of ACEs assessed between children's birth and age seven. We also calculated the cumulative ACE scores of 13 individual ACEs. Cox regression models were used to examine the associations of ACE clusters and scores with risk of premature mortality from adolescence to mid-adulthood.

Findings

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SUBMITTER: Yu J 

PROVIDER: S-EPMC9718480 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature