Cardiovascular disease and subsequent risk of psychiatric disorders: a nationwide sibling-controlled study.

ABSTRACT:

Background

The association between cardiovascular disease (CVD) and selected psychiatric disorders has frequently been suggested while the potential role of familial factors and comorbidities in such association has rarely been investigated.

Methods

We identified 869,056 patients newly diagnosed with CVD from 1987 to 2016 in Sweden with no history of psychiatric disorders, and 910,178 full siblings of these patients as well as 10 individually age- and sex-matched unrelated population controls (N = 8,690,560). Adjusting for multiple comorbid conditions, we used flexible parametric models and Cox models to estimate the association of CVD with risk of all subsequent psychiatric disorders, comparing rates of first incident psychiatric disorder among CVD patients with rate

SUBMITTER: Shen Q 

PROVIDER: S-EPMC9718522 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature