Transcriptome and chromatin alterations in social fear indicate association of MEG3 with successful extinction of fear.

ABSTRACT: Social anxiety disorder is characterized by a persistent fear and avoidance of social situations, but available treatment options are rather unspecific. Using an established mouse social fear conditioning (SFC) paradigm, we profiled gene expression and chromatin alterations after the acquisition and extinction of social fear within the septum, a brain region important for social fear and social behaviors. Here, we particularly focused on the successful versus unsuccessful outcome of social fear extinction training, which corresponds to treatment responsive versus resistant patients in the clinics. Validation of coding and non-coding RNAs revealed specific isoforms of the long non-coding RNA (lncRNA) Meg3 regulated, depending on the success of social fear extinction. Moreover, PI3K/AKT was

SUBMITTER: Royer M 

PROVIDER: S-EPMC9718683 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature