Ozone modified hypothalamic signaling enhancing thermogenesis in the TDP-43^A315T transgenic model of Amyotrophic Lateral Sclerosis.

ABSTRACT: Amyotrophic lateral sclerosis (ALS), a devastating progressive neurodegenerative disease, has no effective treatment. Recent evidence supports a strong metabolic component in ALS pathogenesis. Indeed, metabolic abnormalities in ALS correlate to disease susceptibility and progression, raising additional therapeutic targets against ALS. Ozone (O₃), a natural bioactive molecule, has been shown to elicit beneficial effects to reduce metabolic disturbances and improved motor behavior in TDP-43^A315T mice. However, it is fundamental to determine the mechanism through which O₃ acts in ALS. To characterize the association between O₃ exposure and disease-associated weight loss in ALS, we assessed the mRNA and protein expression profile of molecular pathway

SUBMITTER: Rodriguez-Sanchez S 

PROVIDER: S-EPMC9718766 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature