Brain structure and connectivity in psoriasis and associations with depression and inflammation; findings from the UK biobank.

ABSTRACT:

Background

Psoriasis is a chronic systemic inflammatory skin disease, coexisting with depression in up to 25% of patients. Little is known about the drivers of comorbidity, including shared neurobiology and depression brain imaging patterns in patients. An immune-mediated crosstalk between the brain and skin has been hypothesized in psoriasis. With the aim of investigating brain structure and connectivity in psoriasis in relation to depression comorbidity, we conducted a brain imaging study including the largest psoriasis patient sample to date (to our knowledge) and the first to investigate the role of depression and systemic inflammation in brain measures. Effects of coexisting psoriatic arthritis (PsA), which represents joint involvement in psoriasis and a higher putative inflam

SUBMITTER: Lada G 

PROVIDER: S-EPMC9719019 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature