Evolutionary genetics of flipper forelimb and hindlimb loss from limb development-related genes in cetaceans.

ABSTRACT:

Background

Cetacean hindlimbs were lost and their forelimb changed into flippers characterized by webbed digits and hyperphalangy, thus allowing them to adapt to a completely aquatic environment. However, the underlying molecular mechanism behind cetacean limb development remains poorly understood.

Results

In the present study, we explored the evolution of 16 limb-related genes and their cis-regulatory elements in cetaceans and compared them with that of other mammals. TBX5, a forelimb specific expression gene, was identified to have been under accelerated evolution in the ancestral branches of cetaceans. In addition, 32 cetacean-specific changes were examined in the SHH signaling network (SHH, PTCH1, TBX5, BMPs and SMO), within which mutations could yield webbed digits or a

SUBMITTER: Sun L 

PROVIDER: S-EPMC9719152 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature