Fluid Resuscitation in Patients Presenting with Sepsis: Current Insights.

ABSTRACT: Intravenous (IV) fluid resuscitation is a key component of the initial resuscitation of septic shock, with international consensus guidelines suggesting the administration of at least 30mL/kg of isotonic crystalloid fluid. The rationale is to restore circulating fluid volume and optimise stroke volume. It is acknowledged that there is a paucity of high-level evidence to support this strategy, with most studies being observational or retrospective in design. In the past decade, evidence has emerged that a large positive fluid balance is associated with worse outcomes among patients with septic shock in intensive care who have already received initial resuscitation. Randomised trials undertaken in low-income countries have found increased mortality among patients with sepsis and hypoperfusio

SUBMITTER: Macdonald S 

PROVIDER: S-EPMC9719278 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature