Diagnostics and prospective outcome of a diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters after surgical resection (DGONC): a case report.
Diagnostics and prospective outcome of a diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters after surgical resection (DGONC): a case report.
Project description:As part of a larger study on disseminated pediatric low-grade gliomas, we performed scRNAseq on two diffuse leptomeningeal glioneuronal tumors (DLGNT), one of which remained low-grade, and the other of which underwent high-grade transformation. Using this data, we compared the cellular pathway activation of each tumor, identifying a subpopulation of highly proliferative tumor cells in the transformed sample, which had elevated MAPK pathway activity and depressed p53 pathway activity.