Amine Functionalized Trimetallic Nitride Endohedral Fullerenes: A Class of Nanoparticle to Tackle Low Back/Leg Pain.

ABSTRACT: Low back pain is the most common health problem with a prevalence of over 80% worldwide and an estimated annual cost of $100 billion in the United States. Intervertebral disc degeneration accounts for a major cause of low back pain. However, there is still a lack of safe and effective treatment to tackle this devastating condition. In this study, we synthesized four functionalized trimetallic nitride endohedral metallofullerenes (carboxyl-f-Sc₃N@C₈₀, carboxyl-f-Gd₃N@C₈₀, amino-f-Sc₃N@C₈₀, and amino-f-Gd₃N@C₈₀) and characterized them with X-ray photoelectron spectroscopy, matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and UV-vis. Via electron paramagnetic resonance, all fou

SUBMITTER: Xiao L 

PROVIDER: S-EPMC9719410 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature