Setd2 supports GATA3⁺ST2⁺ thymic-derived Treg cells and suppresses intestinal inflammation.

ABSTRACT: Treg cells acquire distinct transcriptional properties to suppress specific inflammatory responses. Transcription characteristics of Treg cells are regulated by epigenetic modifications, the mechanism of which remains obscure. Here, we report that Setd2, a histone H3K36 methyltransferase, is important for the survival and suppressive function of Treg cells, especially those from the intestine. Setd2 supports GATA3⁺ST2⁺ intestinal thymic-derived Treg (tTreg) cells by facilitating the expression and reciprocal relationship of GATA3 and ST2 in tTreg cells. IL-33 preferentially boosts Th2 cells rather than GATA3⁺ Treg cells in Foxp3^Cre-YFPSetd2 ^flox/flox mice, corroborating the constraint of Th2 responses by Setd2 expression in Treg cells.

SUBMITTER: Ding Z 

PROVIDER: S-EPMC9719510 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature