A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice.

ABSTRACT: Interactions with commensal microbes shape host immunity on multiple levels and play a pivotal role in human health and disease. Tissue-dwelling, antigen-specific T cells are poised to respond to local insults, making their phenotype important in the relationship between host and microbes. Here we show that MHC-II restricted, commensal-reactive T cells in the colon of both humans and mice acquire transcriptional and functional characteristics associated with innate-like T cells. This cell population is abundant and conserved in the human and murine colon and endowed with polyfunctional effector properties spanning classic Th1- and Th17-cytokines, cytotoxic molecules, and regulators of epithelial homeostasis. T cells with this phenotype are increased in ulcerative colitis patients, and thei

SUBMITTER: Hackstein CP 

PROVIDER: S-EPMC9719512 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature