Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis.

ABSTRACT: Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-income countries (LMIC). However, this disease is also spreading in the developed world. Currently, there is a lack of effective strategies to control this disease. Vaccination can be an effective measure to control leishmaniasis and has the potential to achieve disease elimination. Recently, we have generated centrin gene-deleted new world L. mexicana (LmexCen^-/-) parasites using CRISPR/Cas9 and showed that they protect mice against a homologous L. mexicana infection that causes cutaneous disease. In this study, we tested whether LmexCen^-/- parasites can also protect against visceral leishmaniasis caused by L. donovani in a hamster model. We showed t

SUBMITTER: Karmakar S 

PROVIDER: S-EPMC9719514 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature