BNT162b2 induces robust cross-variant SARS-CoV-2 immunity in children.

ABSTRACT: Currently available mRNA vaccines are extremely safe and effective to prevent severe SARS-CoV-2 infections. However, the emergence of variants of concerns (VOCs) has highlighted the importance of high population-based vaccine rates to effectively suppress viral transmission and breakthrough infections. While initially left out from vaccine efforts, children have become one of the most affected age groups and are key targets to stop community and household spread. Antibodies are central for vaccine-induced protection and emerging data points to the importance of additional Fc effector functions like opsononophagocytosis or cytotoxicity, particularly in the context of VOCs that escape neutralizing antibodies. Here, we observed delayed induction and reduced magnitude of vaccine-induced antibo

SUBMITTER: Bartsch YC 

PROVIDER: S-EPMC9719544 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature