Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce-Mn MOF for improved immunotherapy.

ABSTRACT:

Backgrounds

Reversing the immunosuppressive tumor microenvironment (TME) in the tumor is widely deemed to be an effective strategy to improve immune therapy. In particular, the redox balance in TME needs to be well controlled due to its critical role in mediating the functions of various cells, including cancer cells and immune-suppressive cells.

Results

Here, we propose an efficient strategy to reshape the redox homeostasis to reverse immunosuppressive TME. Specifically, we developed a microwave-chemo-immunostimulant CMMCP to promote the infiltration of the tumor-T cells by simultaneously reducing the reactive oxygen species (ROS) and glutathione (GSH) and improving the oxygen (O₂) levels in TME. The CMMCP was designed by loading chemotherapy drugs cisplatin into

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC9719648 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature