An actionable annotation scoring framework for gas chromatography-high-resolution mass spectrometry.

ABSTRACT: Omics-based technologies have enabled comprehensive characterization of our exposure to environmental chemicals (chemical exposome) as well as assessment of the corresponding biological responses at the molecular level (eg, metabolome, lipidome, proteome, and genome). By systematically measuring personal exposures and linking these stimuli to biological perturbations, researchers can determine specific chemical exposures of concern, identify mechanisms and biomarkers of toxicity, and design interventions to reduce exposures. However, further advancement of metabolomics and exposomics approaches is limited by a lack of standardization and approaches for assigning confidence to chemical annotations. While a wealth of chemical data is generated by gas chromatography high-resolution mass spect

SUBMITTER: Koelmel JP 

PROVIDER: S-EPMC9719826 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature