The use of antivirals in the treatment of human monkeypox outbreaks: a systematic review.

ABSTRACT:

Objectives

Human monkeypox virus (MPXV) infection is a recently declared public health emergency of international concern by the World Health Organization. Besides, there is scant literature available on the use of antivirals in MPXV infection. This systematic review compiles all evidence of various antivirals used on their efficacy and safety and summarizes their mechanisms of action.

Methods

A review was done of all original studies mentioning individual patient data on the use of antivirals in patients with MPXV infection.

Results

Of the total 487 non-duplicate studies, 18 studies with 71 individuals were included. Tecovirimat was used in 61 individuals, followed by cidofovir in seven and brincidofovir (BCV) in three individuals. Topical trifluridine was used in fo

SUBMITTER: Shamim MA 

PROVIDER: S-EPMC9719850 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature