A novel thinking: DDR axis refines the classification of ccRCC with distinctive prognosis, multi omics landscape and management strategy

ABSTRACT:

Background

DNA damage response and repair (DDR) related signatures play an important role in maintaining genome stability and other biological processes. It also affects the occurrence, development, and treatment of cancer. However, in renal cell carcinoma (RCC), especially clear cell renal carcinoma (ccRCC), the potential association between DDR-related signatures and tumor heterogeneity and tumor microenvironment (TME) remains unclear.

Methods

Utilizing unsupervised clustering algorithm, we divided RCC into two subgroups, DCS1 and DCS2, according to the differences in DDR gene expression, and compared the characteristics of the two subgroups through multiple dimensions.

Results

Compared with DCS1, DCS2 patients have higher clinical stage/grade and worse prognos

SUBMITTER: Jiang A 

PROVIDER: S-EPMC9720257 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature