APOL1 Genotype, Proteinuria, and the Risk of Kidney Failure: A Secondary Analysis of the AASK (African American Study of Kidney Disease and Hypertension) and CRIC (Chronic Renal Insufficiency Cohort) Studies.

ABSTRACT:

Rationale & objective

Patients with a high-risk Apolipoprotein L1 (APOL1) genotype are more likely to develop chronic kidney disease and kidney failure. It is unclear whether this increased risk is entirely mediated by the development of proteinuria.

Study design

Retrospective observational study of the African American Study of Kidney Disease and Hypertension cohort and Chronic Renal Insufficiency Cohort.

Exposures & predictors

Self-identified race (Black/non-Black) and presence of high-risk APOL1 genotype. The primary model was adjusted for age, sex, diabetes, estimated glomerular filtration rate, and urinary protein-creatinine ratio.

Outcomes

Time to kidney failure defined as time to dialysis or transplantation.

Analytical approach

We us

SUBMITTER: Nguyen A 

PROVIDER: S-EPMC9720339 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature