The centrality of working memory networks in differentiating bipolar type I depression from unipolar depression: A task-fMRI study.

ABSTRACT:

Objectives

Up to 70%-80% of patients with bipolar disorder are misdiagnosed as having major depressive disorder (MDD), leading to both delayed intervention and worsening disability. Differences in the cognitive neurophysiology may serve to distinguish between the depressive phase of type 1 bipolar disorder (BDD-I) from MDD, though this remains to be demonstrated. To this end, we investigate the discriminatory signal in the topological organization of the functional connectome during a working memory (WM) task in BDD-I and MDD, as a candidate identification approach.

Methods

We calculated and compared the degree centrality (DC) at the whole-brain voxel-wise level in 31 patients with BDD-I, 35 patients with MDD, and 80 healthy controls (HCs) during an n-back task. We further e

SUBMITTER: Xi C 

PROVIDER: S-EPMC9720478 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature