Investigation of allele frequencies of polymorphic variants in genes that are related to polycystic ovary syndrome.

ABSTRACT:

Objective

Polycystic ovary syndrome is a hormonal disorder that normally affects women of reproductive age in the range of 18-44 years. This study aimed to investigate the allelic frequencies of two polymorphisms, IRS rs18012781 and INSR rs1799817, which are suspected to be involved in polycystic ovary syndrome.

Methods

The samples were obtained from the patients admitted to the Near East University Hospital, Department of Gynecology and Obstetrics. The samples were divided into two groups: control and polycystic ovary syndrome groups. Blood samples were collected from 55 women in the control group and 65 samples from the patient group. DNA from whole blood was obtained. The allelic frequencies of single-nucleotide polymorphisms were determined using real-time PCR. Results w

SUBMITTER: Adam AR 

PROVIDER: S-EPMC9720763 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature