High thrombus platelet content is associated with a lower rate of first pass effect in stroke treated by endovascular therapy.

ABSTRACT:

Background and purpose

First pass effect (FPE), the occurrence of complete reperfusion after one pass with no rescue attempt during endovascular therapy (EVT), is associated with the best clinical outcome after an acute ischemic stroke (AIS). Previous studies evaluating FPE occurrence according to EVT technical strategies, occlusion locations, or thrombus composition have provided controversial results. Here, we performed a correlation analysis between FPE occurrence and AIS thrombus cellular composition, as assessed using quantitative biochemical assays.

Patients and methods

Homogenates of AIS thrombi from 250 patients were prepared by mechanical grinding. Platelet, red blood cell (RBC), and leukocyte contents of AIS thrombi were respectively estimated by quantification of

SUBMITTER: Delvoye F 

PROVIDER: S-EPMC9720861 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature