Identification of DNA methylation signatures for hepatocellular carcinoma detection and microvascular invasion prediction.

ABSTRACT:

Background and aim

Preoperative evaluation of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC) is important for surgical strategy determination. We aimed to develop and establish a preoperative predictive model for MVI status based on DNA methylation markers.

Methods

A total of 35 HCC tissues and the matched peritumoral normal liver tissues as well as 35 corresponding HCC patients' plasma samples and 24 healthy plasma samples were used for genome-wide methylation sequencing and subsequent methylation haplotype block (MHB) analysis. Predictive models were constructed based on selected MHB markers and 3-cross validation was used.

Results

We grouped 35 HCC patients into 2 categories, including the MVI- group with 17 tissue and plasma samples,

SUBMITTER: Hao Y 

PROVIDER: S-EPMC9720918 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature