Complexity of progranulin mechanisms of action in mesothelioma.

ABSTRACT:

Background

Mesothelioma is an aggressive disease with limited therapeutic options. The growth factor progranulin plays a critical role in several cancer models, where it regulates tumor initiation and progression. Recent data from our laboratories have demonstrated that progranulin and its receptor, EphA2, constitute an oncogenic pathway in bladder cancer by promoting motility, invasion and in vivo tumor formation. Progranulin and EphA2 are expressed in mesothelioma cells but their mechanisms of action are not well defined. In addition, there are no data establishing whether the progranulin/EphA2 axis is tumorigenic for mesothelioma cells.

Methods

The expression of progranulin in various mesothelioma cell lines derived from all major mesothelioma subtypes was examined by wes

SUBMITTER: Ventura E 

PROVIDER: S-EPMC9720952 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature