CD97 serves as a novel biomarker of immune cell infiltration in hepatocellular carcinoma.

ABSTRACT:

Background

CD97 is the most widely expressed G protein-coupled receptor in the epidermal growth factor seven-span transmembrane family. It plays a vital role in cell adhesion, migration, and cell connection regulation. We explored the role of CD97 in hepatocellular carcinoma (HCC).

Methods

We evaluated CD97 mRNA expression in HCC using TNMplot and the Gene Expression Omnibus database. The clinical prognostic significance of CD97 in HCC patients was evaluated by gene expression profiling interactive analysis, the Kaplan-Meier plotter, and the UALCAN database. The Tumor Immune Estimation Resource (TIMER) and CIBERSORT databases were used to analyze the relationships among CD97, genes positively related with CD97, and tumor-infiltrating immune cells.

Results

CD97 was hig

SUBMITTER: Su Q 

PROVIDER: S-EPMC9721038 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature