Addition of probenecid to oral β-lactam antibiotics: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To explore the literature comparing the pharmacokinetic and clinical outcomes from adding probenecid to oral β-lactams.

Methods

Medline and EMBASE were searched from inception to December 2021 for all English language studies comparing the addition of probenecid (intervention) with an oral β-lactam [flucloxacillin, penicillin V, amoxicillin (± clavulanate), cefalexin, cefuroxime axetil] alone (comparator). ROBINS-I and ROB-2 tools were used. Data on antibiotic therapy, infection diagnosis, primary and secondary outcomes relating to pharmacokinetics and clinical outcomes, plus adverse events were extracted and reported descriptively. For a subset of studies comparing treatment failure between probenecid and control groups, meta-analysis was performed.

Results

SUBMITTER: Wilson RC 

PROVIDER: S-EPMC9721384 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature