Adolescent and young adult glioma: systematic review of demographic, disease, and treatment influences on survival.

ABSTRACT:

Background

Prognostic factors in adolescent and young adult (AYA) glioma are not well understood. Though clinical and molecular differences between pediatric and adult glioma have been characterized, their application to AYA populations is less clear. There is a major need to develop more robust evidence-based practices for managing AYA glioma patients.

Methods

A systematic review using PRISMA methodology was conducted using multiple databases with the objective of identifying demographic, clinical, molecular and treatment factors influencing AYA glioma outcomes.

Results

40 Studies met inclusion criteria. Overall survival was highly variable across studies depending on glioma grade, anatomic compartment and cohort characteristics. Thirty-five studies suffered from hig

SUBMITTER: Malhotra AK 

PROVIDER: S-EPMC9721387 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature