Ferritin nanocages as efficient nanocarriers and promising platforms for COVID-19 and other vaccines development.

ABSTRACT:

Background

The development of safe and effective vaccines against SARS-CoV-2 and other viruses with high antigenic drift is of crucial importance to public health. Ferritin is a well characterized and ubiquitous iron storage protein that has emerged not only as a useful nanoreactor and nanocarrier, but more recently as an efficient platform for vaccine development.

Scope of review

This review discusses ferritin structure-function properties, self-assembly, and novel bioengineering strategies such as interior cavity and exterior surface modifications for cargo encapsulation and delivery. It also discusses the use of ferritin as a scaffold for biomedical applications, especially for vaccine development against influenza, Epstein-Barr, HIV, hepatitis-C, Lyme disease, and respir

SUBMITTER: Reutovich AA 

PROVIDER: S-EPMC9721431 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature