Non-invasive Serological Monitoring for Crohn's Disease Postoperative Recurrence.

ABSTRACT:

Introduction

Crohn's disease recurs after intestinal resection. This study evaluated accuracy of a new blood test, the Endoscopic Healing Index [EHI], in monitoring for disease recurrence.

Methods

Patients enrolled in the prospective POCER study [NCT00989560] underwent a postoperative colonoscopic assessment at 6 [2/3 of patients] and 18 months [all patients] following bowel resection, using the Rutgeerts score [recurrence ≥i2]. Serum was assessed at multiple time points for markers of endoscopic healing using the EHI, and paired with the Rutgeerts endoscopic score as the reference standard.

Results

A total of 131 patients provided 437 serum samples, which were paired with endoscopic assessments available in 94 patients [30 with recurrence] at 6 months and 107 patient

SUBMITTER: Hamilton AL 

PROVIDER: S-EPMC9721459 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature